How does calcium trigger neurotransmitter release?
نویسنده
چکیده
Recent work has established that different geometric arrangements of calcium channels are found at different presynaptic terminals, leading to a wide spectrum of calcium signals for triggering neurotransmitter release. These calcium signals are apparently transduced by synaptotagmins - calcium-binding proteins found in synaptic vesicles. New biochemical results indicate that all synaptotagmins undergo calcium-dependent interactions with membrane lipids and a number of other presynaptic proteins, but which of these interactions is responsible for calcium-triggered transmitter release remains unclear.
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عنوان ژورنال:
- Current opinion in neurobiology
دوره 11 3 شماره
صفحات -
تاریخ انتشار 2001